When it comes to pain and inflammation management, particularly in the case of arthritis, injuries and recovery after surgery, Zerodol is widely used by medical practitioners. It brings together the potency of a blend of three active constituents-Aceclofenac, Paracetamol (Acetaminophen), Serratiopeptidase to provide strong pain relief and also help with a fever and swelling. This article will comprise all the information you need to know about Zerodol SP, its uses, benefits, dosage, precautions, side effects and frequently asked questions.
Table of Contents
What is Zerodol SP?

Zerodol is a combination drug from Ipca Labs and is used for the treatment of various types of pain and inflammation. It is generally beneficial for managing musculoskeletal pain, postoperative inflammation, arthritis and swelling due to injury. The three efficacious drug components-Aceclofenac, Paracetamol, Serratiopeptidase work in concert and synergistically to relieve pain and swelling, bringing both an analgesic and an anti-inflammatory effect.
Let’s do a breakdown of the major components:
- Aceclofenac (100 mg): A non-steroidal anti-inflammatory drug (Nsaid) that helps in pain and inflammation reduction.
- Paracetamol (325 mg): It is an analgesic and an antipyretic, which is used for pain management and fever reduction.
- Serratiopeptidase (15 mg): An enzyme to alleviate inflammation and restore it by breaking down abnormal protein amino acids at the height of inflammation.
Key Benefits of Zerodol SP
Zerodol SP is used in relieving pain rapidly and for a longer period; the pain may lie between mild and severe. the many advantages are
- Effective Pain Relief: Whether it’s joint pain, dental pain, or muscle pain, Zerodol provides quick and lasting relief.
- Anti-Inflammatory Action: The inclusion of serratiopeptidase boosts the anti-inflammatory potential, making it suitable for post-surgical and trauma recovery.
- Fever Reduction: Paracetamol helps in decreasing the fever, making it a generic medicine.
- Increased Mobility: It increases mobility in people suffering from arthritis or injury-related joint stiffness by means of easing out the pain and swelling.
- Additional Recovery: Extremely helpful following the surgeries and sports injuries to facilitate faster recovery, eliminating the swelling and pain.
Common Medical Conditions Treated by Zerodol SP
Here are the conditions for which Zerodol is typically prescribed:
- Rheumatoid Arthritis
- Osteoarthritis
- Spondylitis
- Post-operative pain
- Dental pain
- Back pain
- Muscle spasms
- Sprains and strains
- Trauma and injury swelling
How Zerodol SP Works (Mechanism of Action)
Each component in Zerodol SP plays a unique role in its action:
- Aceclofenac inhibits cyclooxygenase (COX) enzymes, thereby reducing the formation of prostaglandins—chemical messengers responsible for pain and inflammation.
- Paracetamol acts centrally in the brain to reduce the perception of pain and bring down fever.
- Serratiopeptidase is an enzyme that helps break down inflammatory proteins at the site of swelling or injury, enhancing the anti-inflammatory effect.
This triple combination makes Zerodol a powerful solution for both acute and chronic pain management.
Zerodol SP Dosage and Administration
The dosage of Zerodol varies based on the patient’s age, medical history, and the severity of the condition. However, standard dosage guidelines are as follows:
Patient Type | Typical Dosage | Frequency | Notes |
Adults | 1 tablet | Twice daily (morning and evening) | After meals to avoid gastric irritation |
Elderly | As prescribed by doctor | Usually lower doses | Monitor for kidney/liver function |
Children | Not recommended | – | Only if prescribed by a pediatrician |
Who Should Avoid Zerodol SP?
Zerodol SP should be taken with caution by some people, or they should completely avoid taking it. These include:
- Pregnant and feeding women (except on prescription)
- Children under 12 years
- Patients with peptic ulcers or gastrointestinal bleeding
- People with severe liver or kidney disease
- Individuals allergic to NSAIDs or any of the ingredients
- Give a detailed medical history of yourself before taking Zerodol.
Interactions with Other Medications
Zerodol SP may interact with some medications, such as augmenting side effects or diminishing effectiveness. Use with caution if administration of any one of the following is planned or has occurred within the past 2 weeks:
- Blood thinners (e.g., warfarin)
- Other NSAIDs or painkillers
- Antibiotics like ciprofloxacin
- Steroids
- Diuretics and antihypertensive drugs
- Antiepileptic drugs
To minimize interactions, tell your doctor about all prescribed and unprescribed medications and supplements.
Side Effects of Zerodol SP
While Zerodol is generally well-tolerated, like all medications, it may have some side effects. These can range from mild to severe depending on individual health conditions and dosage.
Common Side Effects:
- Nausea
- Heartburn
- Diarrhea
- Dizziness
- Stomach discomfort
Less Common/Severe Side Effects:
- Gastrointestinal ulcers
- Kidney function issues
- Elevated liver enzymes
- Allergic skin reactions
- Breathing difficulty (rare)
Important Note:
If you experience any severe side effects or allergic reactions such as swelling of the face/lips, breathing difficulty, or intense skin rash, discontinue the medicine and seek immediate medical attention.
Tips for Safe Use of Zerodol SP
Some important precautions and tips for the use of Zerodol SP are as follows:
- Take the medication with meals to reduce stomach troubles.
- Keep drinking water during the day.
- To avoid any form of alcohol poisoning with Zerodol, refrain from alcohol.
- Do not take several painkillers at the same time without consulting your doctor.
- Zerodol prolonged use may cause the monitoring of kidney and liver functions.
Ignore the missed dose if it’s almost time to take your next dose. If the next dose is almost due, miss the forgotten one.
Zerodol SP vs. Zerodol P: What’s the Difference?
While both medicines are from the same brand and serve similar functions, there are differences:
Feature | Zerodol SP | Zerodol P |
Composition | Aceclofenac + Paracetamol + Serratiopeptidase | Aceclofenac + Paracetamol |
Anti-inflammatory effect | Higher (due to Serratiopeptidase) | Moderate |
Use Cases | Severe swelling, post-op pain | Mild to moderate pain |
Availability | Prescription only | Prescription only |
Zerodol SP is more potent and better suited for severe inflammatory pain, while Zerodol P is ideal for general pain and fever management.
Frequently Asked Questions (FAQs)
Q1. Can Zerodol SP be used for toothache?
Ans: Yes, Zerodol SP is often prescribed for dental pain, including after tooth extraction, as it helps reduce both pain and swelling.
Q2. Is it safe to take Zerodol SP daily?
Ans: Short-term use as prescribed by a doctor is safe. Long-term use requires monitoring due to potential risks to the liver, kidneys, and stomach.
Q3. Can I take Zerodol SP on an empty stomach?
Ans: It is advised to take Zerodol SP after meals to reduce the chances of gastric discomfort and ulcers.
Q4. Is Zerodol SP a steroid?
Ans: No, it is not a steroid. It is a combination of a painkiller (NSAID), a fever reducer, and an anti-inflammatory enzyme.
Final Thoughts
Zerodol SP is a highly effective medication for managing moderate to severe pain, especially when accompanied by inflammation. Its powerful combination of Aceclofenac, Paracetamol, and Serratiopeptidase makes it a preferred choice in orthopedic, surgical, and dental settings. However, like all potent medicines, it must be used responsibly, under medical supervision, and never as a self-medicated option.
If you are dealing with acute inflammation or post-injury pain, consult your doctor to see if Zerodol SP is the right choice for you. With the right dosage and precautions, it can significantly enhance your quality of life during painful conditions.
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